Withaferin A is extracted from leaves of Withania somnifera (a
| ||Withaferin A is a cell-permeable
steroidal lactone from a medicinal plant Withania somnifera, a plant known
in traditional Indian medicine.|
|CAS number: ||5119-48-2|
|Merck index: ||
|Molecular weight: ||470.6|
|Molecular Formula: ||C28H38O6|
|Appearance: ||White to off-white
|Purity: ||At least 97% by TLC;
Current lot: single stain|
At least 98% by HPLC; current lot WT001 99%
335 nm (in ethanol)|
|Solubility||Clear colorless solution at 20
Clear colorless solution at 10 mg/ml MeOH
Solutions are stable
for up to 3 months at -20°C.
|Applications||Withaferin A has
shown significant anticancer activity in animal studies|
Withaferin A is an angiogenesis inhibitor .
Withaferin A has immunomodulating properties.
Withaferin A has radiosensitizing effect on cancer cells.
Withaferin A has been reported to induce neuronal regeneration.
|Warnings||To our knowledge, the
pharmacological and toxicological properties of Withaferin A have not
been fully investigated.|
Toxic, carcinogenic and mutagenic in animals
inhibitor of angiogenesis
|Related products|| |
| ||For Research use only. Not
for Human or Drug use|
GMP/API grade available on request
raw materials from
animal source were used.
by Fermentek is not produced from or contains any ingredients from animal
No genetically modified organisms are used.
| ||Yang H, Shi G, Dou QP.|
Pharmacol. 2007 Feb;71(2):426-37.
The tumor proteasome is a primary target for the natural anticancer compound
Withaferin A isolated from "Indian winter cherry"
| ||Uma Devi P, Kamath R.|
Res (Tokyo). 2003 Mar;44(1):1-6
Radiosensitizing effect of withaferin A combined with hyperthermia on mouse
fibrosarcoma and melanoma.
| ||Sudhir S, Budhiraja RD.|
J Physiol Pharmacol. 1992 Apr;36(2):127-9
Comparison of the protective effect of Withaferin-A and hydrocortisone
against CCL4 induced hepatotoxicity in rats
| ||Srinivasan S, Ranga RS, Burikhanov
R, Han SS, Chendil D.|
Cancer Res. 2007 Jan 1;67(1):246-53
Par-4-dependent apoptosis by withaferin A in prostate cancer cells.
| ||Shohat B, Kirson I, Lavie D|
Biomedicine. 1978 Jan-Feb;28(1):18-24
Immunosuppressive activity of two plant steroidal lactones withaferin A and
| ||Shohat B, Shaltiel A, Ben-Bassat
M, Joshua H.|
Cancer Lett. 1976 Nov;2(2):71-7.
The effect of withaferin A, a natural steroidal lactone, on the fine
structure of S-180 tumor cells
| ||Sharada AC, Solomon FE, Devi PU,
Udupa N, Srinivasan KK.|
Acta Oncol. 1996;35(1):95-100
Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich
ascites carcinoma in vivo.
| ||Sen N, Banerjee B, Das BB, Ganguly
A, Sen T, Pramanik S, Mukhopadhyay S, Majumder HK.|
Cell Death Differ.
2007 Feb;14(2):358-67. Epub 2006 Jul 14
Apoptosis is induced in leishmanial cells by a novel protein kinase
inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA
| ||Rosazza JP, Nicholas AW, Gustafson
Steroids. 1978 May;31(5):671-9.
Microbial transformations of natural antitumor agents. 7.
14-alpha-Hydroxylation of withaferin-A by Cunninghamella elegans (NRRL
| ||Malik F, Kumar A, Bhushan S, Khan
S, Bhatia A, Suri KA, Qazi GN, Singh J.|
oxygen species generation and mitochondrial dysfunction in the apoptotic
cell death of human myeloid leukemia HL-60 cells by a dietary compound
withaferin A with concomitant protection by N-acetyl cysteine.
| ||Kaileh M, Vanden Berghe W,
Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T,
J Biol Chem. 2007 Feb 16;282(7):4253-64
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation
concomitant with potent inhibition of its kinase activity
| ||Fuskova A, Fuska J, Rosazza JP,
Novel cytotoxic and antitumor
agents. IV. Withaferin A:
relation of its structure to the in vitro cytotoxic effects on P388 cells.
| ||Fuska J, Prousek J, Rosazza J,
Steroids. 1982 Aug;40(2):157-69
transformations of natural antitumor agents. 23.
Conversion of withaferin-A to 12 beta- and 15 beta-hydroxy derivatives of
| ||Devi PU, Akagi K, Ostapenko V,
Tanaka Y, Sugahara T.|
Int J Radiat Biol. 1996 Feb;69(2):193-7
Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania
| ||Devi PU, Sharada AC, Solomon FE.|
Cancer Lett. 1995 Aug 16;95(1-2):189-93
In vivo growth inhibitory and radiosensitizing effects of withaferin A on
mouse Ehrlich ascites carcinoma.
| ||Bargagna-Mohan P, Hamza A, Kim YE,
Khuan Abby Ho Y, Mor-Vaknin N, Wendschlag N, Liu J, Evans RM, Markovitz DM,
Zhan CG, Kim KB, Mohan R.|
Chem Biol. 2007 Jun;14(6):623-34
The tumor inhibitor and antiangiogenic agent withaferin A targets the
intermediate filament protein vimentin.
Sudhir S, Budhiraja RD.
Indian J Physiol Pharmacol. 1992 Apr;36(2):127-9
Comparison of the protective
effect of Withaferin-A and hydrocortisone against CCL4 induced hepatotoxicity in