| Source: |
Penicillium simplicissimum |
| Synonyms | |
| Description: | Verruculogen is a
tremorgenic mycotoxin. |
| CAS number: | 12771-72-1 |
| Merck index: | 14: not
listed |
| Molecular weight: | 511.6 |
| Structure: | 
 |
| Molecular Formula: | C27H33N3O7 |
| Canonical SMILES: |
CC(=CC1N2C3=C(C=CC(=C3)OC)C4=C2C(CC(OO1)(C)C)N5C(=O)C6CCCN6C(=O)C5(C4O)O)C |
Solubility
information: | DMSO,
Methanol, Ethanol |
| Specifications | |
| Appearance: | White powder |
| Purity: |
At least 95% by TLC, HPLC |
λmax: |
|
| Melting point | 230°C -233°C |
| Solubility | |
| Storage | -20°C. |
| Applications | Verruculogen
decreases GABA levels in CNS.
Tremorgenic doses of verruculogen
increase the number and decrease the affinity of DHP receptors in rat
cortex.
Verruculogen is a potent inhibitor of high
conductance Ca activated K (maxi-K) channel. |
| Classification |
tremorgen mycotoxin |
| Warnings |
 TOXIC |
| Related products | |
| | For Research use only. Not
for Human or Drug use
GMP/API grade available on request
No
genetically modified organisms are used. |
| Publications | |
| | Kosalec I, Klaric MS, Pepeljnjak
S.
Verruculogen production in airborne and clinical isolates of Aspergillus
fumigatus Fres.
Acta Pharm. 2005 Dec;55(4):357-64 |
| | Sabater-Vilar M, Nijmeijer S,
Fink-Gremmels J.
Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B,
paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds
isolated from fermented meats.
J Food Prot. 2003 Nov;66(11):2123-9 |
| | BMC Microbiol. 2007 Jan 23;7:5.
Verruculogen associated with Aspergillus fumigatus hyphae
and conidia modifies the electrophysiological properties of
human nasal epithelial cells.
Khoufache K, Puel O, Loiseau N, Delaforge M, Rivollet D,
Coste A, Cordonnier C, Escudier E, Botterel F, Bretagne S. |
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