|
Source: | Streptomyces fulvissimus |
| Synonyms |
Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
HSDB 6423
EINECS 217-896-6 |
| Description: | Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. |
| CAS number: | 2001-95-8 |
| Merck index: | 13, 9976 |
| Molecular weight: | 1111.4 |
| Structure: |
 |
| Molecular Formula: |
C54H90N6O18
|
| Canonical SMILES: |
CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)N C(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C (C)C)C(C)C)C)C(C)C)C(C)C)C(C)C |
Solubility
information: | Soluble in Ether, Benzene, Chloroform, Glacial acetic acid, Butyl acetate, Acetone, Methanol, Ethanol, Ethyl acetate, Petrol-ether, Dichloromethane.
Water insoluble |
| Specifications |
|
| Appearance: | White crystalline solid. |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | 220 |
| Melting point: | 187°C -189°C |
| Solubility: | |
| Storage: | -20°C. Protect from light. |
| Applications: |
Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes.
Valinomycin is an apoptosis inducer. It is used as a tool in membrane research. |
| Classification: | cyclic
oligopeptide
Ionophore |
| Related products: |
Nonactin |
| Warnings: | Eye irritant |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Valinomycin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications |
|
| |
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10012-7.
Valinomycin is targeting severe acute respiratory syndrome human coronavirus.
Wu CY et al |
| | Ryoo IJ, Park HR, Choo SJ, Hwang JH, Park YM, Bae KH, Shin-Ya K, Yoo ID.
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
Biol Pharm Bull. 2006 Apr;29(4):817-20 |
| | Naumowicz M, Kotynska J, Petelska A, Figaszewski Z.
Impedance analysis of phosphatidylcholine membranes modified with valinomycin.
Eur Biophys J. 2006 Feb;35(3):239-46 |
| | Becucci L, Moncelli MR, Naumann R, Guidelli R.
Potassium ion transport by valinomycin across a Hg-supported lipid bilayer.
J Am Chem Soc. 2005 Sep 28;127(38):13316-23 |
| | Vredenberg WJ, Bulychev A.
Photoelectric effects on chlorophyll fluorescence of photosystem II in vivo. Kinetics in the absence and presence of valinomycin.
Bioelectrochemistry. 2003 Aug;60(1-2):87-95 |
| |
Abdalah R, Wei L, Francis K, Yu SP.
Valinomycin - induced apoptosis in Chinese hamster ovary cells.
Neurosci Lett. 2006 Jul 18
|
| |
Immobilized valinomycin molecule for K+ sensor,
United States Patent 4973394 |
|
Process for controlling insects,nematodes and mites
using valinomycin,
US patent 3520973 |
