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cancer research reagents

Valinomycin

MSDS Sample CoA
 
Source: Streptomyces fulvissimus
Synonyms Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
HSDB 6423
EINECS 217-896-6
Description: Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins.
CAS number: 2001-95-8
Merck index: 13, 9976
Molecular weight: 1111.4
Structure:

 

Molecular Formula: C54H90N6O18
Canonical SMILES: CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)N C(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C (C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
Solubility
information:
Soluble in Ether, Benzene, Chloroform, Glacial acetic acid, Butyl acetate, Acetone, Methanol, Ethanol, Ethyl acetate, Petrol-ether, Dichloromethane.
Water insoluble
Specifications  
Appearance: White crystalline solid.
Purity: At least 97% by TLC, HPLC
λmax: 220
Melting point:187°C -189°C
Solubility:  
Storage: -20°C. Protect from light.
Applications: Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes.
Valinomycin is an apoptosis inducer. It is used as a tool in membrane research.
Classification: cyclic oligopeptide
Ionophore
Related products:  Nonactin 
Warnings:

Eye irritant

 For Research use only. Not for Human or Drug use
GMP/API grade available on request
Valinomycin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
Publications  
  Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10012-7.
Valinomycin is targeting severe acute respiratory syndrome human coronavirus.
Wu CY et al
 Ryoo IJ, Park HR, Choo SJ, Hwang JH, Park YM, Bae KH, Shin-Ya K, Yoo ID.
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
Biol Pharm Bull. 2006 Apr;29(4):817-20
 Naumowicz M, Kotynska J, Petelska A, Figaszewski Z.
Impedance analysis of phosphatidylcholine membranes modified with valinomycin.
Eur Biophys J. 2006 Feb;35(3):239-46
 Becucci L, Moncelli MR, Naumann R, Guidelli R.
Potassium ion transport by valinomycin across a Hg-supported lipid bilayer.
J Am Chem Soc. 2005 Sep 28;127(38):13316-23
 Vredenberg WJ, Bulychev A.
Photoelectric effects on chlorophyll fluorescence of photosystem II in vivo. Kinetics in the absence and presence of valinomycin.
Bioelectrochemistry. 2003 Aug;60(1-2):87-95
 

Abdalah R, Wei L, Francis K, Yu SP.
Valinomycin - induced apoptosis in Chinese hamster ovary cells.
Neurosci Lett. 2006 Jul 18

  Immobilized valinomycin molecule for K+ sensor, United States Patent 4973394
Process for controlling insects,nematodes and mites using valinomycin, US patent 3520973


Valinomycin on Wikipedia
Clinical perspectives of valinomycin

Valinomycin is active against SARS coronavirus


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