| Source: | Streptomyces
chartreusis |
| Synonyms | |
| Description: | Tunicamycin is a mixture of
homologous nucleoside antibiotics. |
| CAS number: | 11089-65-9 |
| Merck index: | 12, 9949 |
| Molecular weight: | 840.0 (for n = 10) |
| Structure: |
 |
| Molecular Formula: | C39H64N4O16 (for n=10) |
Solubility
information: | Tunicamycin is soluble in DMSO, alkaline water, hot methanol |
| Specifications |
|
| Appearance: | White crystalline solid. |
| Purity: | At least 98% by TLC, HPLC |
λmax: | (In methanol) 205,260 |
| Melting point | Tunicamycin decomposes at 234°C - 235°C |
| Solubility | Clear solution at 50mg/ml of DMSO |
| Storage | -20°C. |
| Applications | Tunicamycins inhibit protein glycosylation. They arrest cell cycle in late G1 |
| Warnings | Tunicamycin is potentially harmful or fatal if swallowed,
inhaled, or absorbed through the skin. |
| Classification | nucleoside antibiotic
antiviral
proteins glucosylation inhibitor |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications |
|
| | Delom F, Emadali A, Cocolakis E, Lebrun JJ, Nantel A, Chevet E.
Calnexin-dependent regulation of tunicamycin-induced apoptosis in breast carcinoma MCF-7 cells.
Cell Death Differ. 2006 Jul 21 |
| | Horikawa K, Oishi N, Nakagawa J, Kasai A, Hayakawa K, Hiramatsu N, Takano Y, Yokouchi M, Yao J, Kitamura M.
Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor - dioxin responsive element signaling pathway.
FEBS Lett. 2006 Jun 26;580(15):3721-5. | |
|
