| Source: | Streptomyces platensis |
| Synonyms | Antibiotic A300
do not confuse with TRICHOSANTHIN |
| Description: | Trichostatin A is an antifungal antibiotic. Trichostatin A is a potent, reversible inhibitor of histone deacetylase. |
| CAS number: | 58880-19-6 |
| Merck index: | 12, 9781 |
| Molecular weight: | 302.4 |
| Structure: | 
 |
| Molecular Formula: | C17H22N2O3 |
Solubility
information: | DMSO, Ethanol |
| Specifications | |
| Appearance: | Off-white powder |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | 265, 340 |
| Melting point | 141°C -143°C |
| Solubility | |
| Storage | -20°C |
| Applications | |
| Classification | HDAC inhibitor |
| Warnings | Trichostatin A is harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Trichostatin A may cause sensitization by skin contact. |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications |
|
| | Chen J, Bai H, Wang C, Kang J.
Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6. |
| | Okamoto H, Fujioka Y, Takahashi A, Takahashi T, Taniguchi T, Ishikawa Y, Yokoyama M.
Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits Smooth Muscle Cell Proliferation via Induction of p21(WAF1).
J Atheroscler Thromb. 2006 Aug;13(4):183-91. |
| | Donadelli M, Costanzo C, Beghelli S, Scupoli MT, Dandrea M, Bonora A, Piacentini P, Budillon A, Caraglia M, Scarpa A, Palmieri M.
Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.
Biochim Biophys Acta. 2007 Jul;1773(7):1095-106 |
| | Piotrowska H, Jagodzinski PP.
Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines.
Biomed Pharmacother. 2007 Apr 20 |
| | Horion J, Gloire G, El Mjiyad N, Quivy V, Vermeulen L, Vanden Berghe W, Haegeman G, Van Lint C, Piette J, Habraken Y.
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.
J Biol Chem. 2007 May 25;282(21):15383-93 |
| | Epigenetic mechanisms
re-establish access to long-term memory after neuronal loss :
applications on Trichostatin, Apicidin from Fermentek, United States Patent
Application 20080300205 | |
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Streptomyces platensis
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