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cancer research reagents

Trichostatin A

MSDSSample CoARaw materials from animal origin info
 
Source: Streptomyces platensis
Synonyms Antibiotic A300

do not confuse with TRICHOSANTHIN

Description: Trichostatin A is an antifungal antibiotic. Trichostatin A is a potent, reversible inhibitor of histone deacetylase.
CAS number: 58880-19-6
Merck index: 12, 9781
Molecular weight: 302.4
Structure:

trichostatin A, molecular structure. Thrichostatin is for sale, the picture is Free to copy

 

Molecular Formula: C17H22N2O3
Canonical SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Solubility
information:
DMSO, Ethanol
Specifications  
Appearance: Off-white powder
Purity: At least 97% by TLC, HPLC
λmax: 265, 340
Melting point 141°C -143°C
Solubility
Storage -20C
Applications
Classification HDAC inhibitor
Warnings Trichostatin A is harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Trichostatin A may cause sensitization by skin contact.
Related products
 For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
Publications  
 Chen J, Bai H, Wang C, Kang J.
Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6.
 Okamoto H, Fujioka Y, Takahashi A, Takahashi T, Taniguchi T, Ishikawa Y, Yokoyama M.
Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits Smooth Muscle Cell Proliferation via Induction of p21(WAF1).
J Atheroscler Thromb. 2006 Aug;13(4):183-91.
 Donadelli M, Costanzo C, Beghelli S, Scupoli MT, Dandrea M, Bonora A, Piacentini P, Budillon A, Caraglia M, Scarpa A, Palmieri M.
Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.
Biochim Biophys Acta. 2007 Jul;1773(7):1095-106
 Piotrowska H, Jagodzinski PP.
Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines.
Biomed Pharmacother. 2007 Apr 20
 Horion J, Gloire G, El Mjiyad N, Quivy V, Vermeulen L, Vanden Berghe W, Haegeman G, Van Lint C, Piette J, Habraken Y.
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.
J Biol Chem. 2007 May 25;282(21):15383-93
  Epigenetic mechanisms re-establish access to long-term memory after neuronal loss : applications on Trichostatin, Apicidin from Fermentek, United States Patent Application 20080300205


Streptomyces platensis produces trichostatin A

Streptomyces platensis

 

 


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