| Source: | Thapsia garganica (Plant extract) |
| Synonyms | |
| Description: | Thapsigargin is a cell-permeable, tumor promoting sesquiterpene lactone. A tight-binding inhibitor of intracellular calcium (SERCA) pumps. |
| CAS number: | 67526-95-8 |
| Merck index: | 13, 9342 |
| Molecular weight: | 650.8 |
| Structure: | 
 |
| Molecular Formula: |
C34H50O12 |
Solubility
information: | DMSO, Acetonitril, Ethanol, Methanol, Dichloromethane |
| Specifications | |
| Appearance: | Clear Colorless Film |
| Purity: | Single stain on TLC
At least 95% by HPLC |
| λmax: | |
| Melting point | |
| Solubility | Clear colorless solution at 10mg/ml Acetonitril |
| Storage | -20°C. Protect from light. |
| Applications | |
| Classification | Sesquiterpene lactone
SERCA inhibitor
Apoptosis related antibiotic |
| Warnings | Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation. Potentially carcinogenic. |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Gonzalez A, Granados MP, Pariente JA, Salido GM.
H2O (2) Mobilizes Ca2+ from Agonist- and Thapsigargin -sensitive and Insensitive Intracellular Stores and Stimulates Glutamate Secretion in Rat Hippocampal Astrocytes.
Neurochem Res. 2006 Jun;31(6):741-50 |
| | O'neill JP, Velalar CN, Lee DI, Zhang B, Nakanishi T, Tang Y, Selaru F, Ross D, Meltzer SJ, Hussain A.
Thapsigargin resistance in human prostate cancer cells.
Cancer. 2006 Jun 12 |
| | Kmonickova E, Canova NK, Farghali H, Holy A, Zidek Z.
Modulator of intracellular Ca(2+), Thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):321-4. |
| | Feng XQ, You Y, Xiao J, Zou P.
Thapsigargin-induced apoptosis of K562 cells and its mechanism
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Feb;14(1):25-30. |
| | Zhang HN, Zhou JG, Qiu QY, Ren JL, Guan YY.
ClC-3 chloride channel prevents apoptosis induced by thapsigargin in PC12 cells.
Apoptosis. 2006 Mar;11(3):327-36 |
| | Yoshida I, Monji A, Tashiro K, Nakamura K, Inoue R, Kanba S.
Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells.
Neurochem Int. 2006 Jun;48(8):696-702. |
| | Sohoel H, Liljefors T, Ley SV, Oliver SF, Antonello A, Smith MD, Olsen CE, Isaacs JT, Christensen SB.
Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin.
J Med Chem. 2005 Nov 3;48(22):7005-11. |
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