| Source: | Taxus brevifolia ( a plant extract) |
| Synonyms | Paclitaxel |
| Description: | Taxol: an antineoplastic agent from a plant extract. Taxol stabilizes microtubules in their polymerized form thus leading to cell death |
| CAS number: | 33069-62-4 |
| Merck index: | 12, 7117 |
| Molecular weight: | 853.9 |
| Structure: | 
 |
| Molecular Formula: | C47H51NO14 |
Solubility
information: | DMSO, Methanol, Ethanol. Unstable in Methanol. |
| Specifications | |
| Appearance: | White crystalline solid. |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | 227, 273 |
| Melting point | (decomposition) 200°C-220°C |
| Solubility | Clear colorless solution at 10mg/ml of Methanol. |
| Storage | -20°C. Protect from light. |
| Applications | A antineoplastic drug.
A tool in Microtubuli research |
| Warnings | Warning! May cause birth defects. Irritates eyes, skin, respiratory system |
| Classification | cyclodecane
Antitumor
agent |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
taxol by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Lu H, Li B, Kang Y, Jiang W, Huang Q, Chen Q, Li L, Xu C.
Taxol nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting.
Cancer Chemother Pharmacol. 2006 May 23 |
| | Kakolyris S, Agelidou A, Androulakis N, Tsaroucha E, Kouroussis C, Agelidou M, Karvounis N, Veslemes M, Christophylakis C, Argyraki A, Geroyianni A, Georgoulias V.
Cisplatin plus etoposide chemotherapy followed by thoracic irradiation and taxol plus cisplatin consolidation therapy for patients with limited stage small cell lung carcinoma.
Lung Cancer. 2006 May 20 |
| | Peltier S, Oger JM, Lagarce F, Couet W, Benoit JP.
Enhanced Oral taxol Bioavailability After Administration of taxol -Loaded Lipid Nanocapsules.
Pharm Res. 2006 May 25 |
| | Reck M, von Pawel J, Macha HN, Kaukel E, Deppermann KM, Bonnet R, Ulm K, Hessler S, Gatzemeier U.
Efficient palliation in patients with small-cell lung cancer by a combination of taxol , etoposide and carboplatin: Quality of life and 6-years'-follow-up results from a randomised phase III trial.
Lung Cancer. 2006 May 17 |
| | Dias ML, Carvalho JP, Rodrigues DG, Graziani SR, Maranhao RC.
Pharmacokinetics and tumor uptake of a derivatized form of taxol associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers.
Cancer Chemother Pharmacol. 2006 May 13 |
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Taxus brevifolia |
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