| Source: | Streptomyces staurosporeus |
| Synonyms | (+)-Staurosporine
AM-2282
Alkaloid AM-2282 from Streptomyces
Antibiotic 230
Antibiotic AM 2282
CCRIS 3272
Staurosporin
Staurosporine |
| Description: | Staurosporin is a cell permeable inhibitor of protein kinases, including protein kinase-C. |
| CAS number: | 62996-74-1 |
| Merck index: | Not
listed |
| Molecular weight: | 466.5 |
| Structure: |
|
| Molecular Formula: | C28H26N4O3 |
Solubility
information: | DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble |
| Specifications | |
| Appearance: | Off-white to light yellow powder |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | (in Methanol) 208, 241, 292, 334, 355, 373 |
| Melting point | 237°C-239°C |
| Solubility | Clear colorless solution at 5mg/ml Ethyl Acetate |
| Storage | +4°C. Protect from light. |
| Applications | May participate in antigen-induced T-cell activation
Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2 |
| Classification | indolocarbazole alkaloid
PKC inhibitor |
| Warnings | Potentially irritant |
| Related products |
KT5853 , KT5720 , staurosporin , PKC412
K252a , K252B K252c
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Howard-Jones AR, Walsh CT.
staurosporin and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid.
J Am Chem Soc. 2006 Sep 20;128(37):12289-98. |
| | Zhang Y, Qin K, Wang J, Hung T, Zhao RY.
staurosporin Dividing roles of prion protein in staurosporin-mediated apoptosis.
Biochem Biophys Res Commun. 2006 Aug 28 |
| | Andrioli LP, Souza GM, da Silva AM.
staurosporin induces tyrosine phosphorylation in Dictyostelium discoideum proteins.
Cell Biochem Funct. 2006 Aug 21; |
| | Langford MP, Chen D, Gosslee J, Misra RP, Redens TB, Texada DE.
Intracameral toxicity of bacterial components muramyl dipeptide and staurosporin: ciliary cyst formation, epithelial cell apoptosis and necrosis.
Cutan Ocul Toxicol. 2006;25(2):85-101. Review. |
| | Harmalkar MN, Shirsat NV.
staurosporin-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.
Neurochem Res. 2006 May;31(5):685-92 |
| | Applications of KT 5720, K252a and
K525b from Fermentek in methods for quantitative analysis of captured
kinases and proteases, see United States Patent Application 20090253156 |
| | Using Staurosporin from Fermentek as
starting material for preparation of UCN-01, UCN-02, see United States
Patent 6197955 |
