| Source: | Euphorbia resinifera (Resin spurge) |
| Synonyms | TRX, Reciniferatoxin |
| Description: | Phorbol related diterpene ester; potent agonist of vanilloid TRPV1 receptors Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in sensory neurons involved in transmission of pain signals. |
| CAS number: | 57444-62-9 |
| Merck index: | not listed |
| Molecular weight: | 628.7 |
| Structure: | |
| Molecular Formula: | C37H40O9 |
Solubility
information: | Insoluble in water. Soluble in DCM, Methanol, Ethanol |
| Specifications | |
| Appearance: | White crystalline powder. |
| Purity: | At least 97% by TLC |
| λmax: | No UV adsorption |
| Melting point | 175°C-185°C |
| Solubility | Clear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml methanol |
| Storage | -20°C. |
| Applications | Resiniferatoxin has been used to label the vanilloid receptor in sensory ganglia.
Resiniferatoxin activates protein kinase C. |
| | |
| Warnings |  Toxic.  Irritant. |
| Classification | diterpene
vanilloid receptoractivator
PKC activator |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
resiniferatoxin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| |
John K Neubert, Andrew J, Mannes, Laszlo J, Karai, Alan C, Jenkins, Lanel Zawatski, Mones Abu-Asab, Michael J Iadarola
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
Molecular Pain 2008, 4:3 |
| | Tang W, Song B, Zhou ZS, Lu GS.
Chin Med J (Engl). 2007 Sep 20;120(18):1616-21.
Intrathecal administration of resiniferatoxin produces analgesia against prostatodynia in rats. |
