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cancer research reagents

Resiniferatoxin

MSDSSample CoA
 
Source: Euphorbia resinifera (Resin spurge)
SynonymsTRX, Reciniferatoxin
Description: Phorbol related diterpene ester; potent agonist of vanilloid TRPV1 receptors

Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in  sensory neurons involved in transmission of pain signals.

CAS number: 57444-62-9
Merck index: not listed
Molecular weight: 628.7
Structure:
resiniferatoxin pure for sale by Fermentek

 

Molecular Formula: C37H40O9
Canonical SMILES:  
Solubility
information:
Insoluble in water. Soluble in DCM, Methanol, Ethanol
Specifications 
Appearance: White crystalline powder.
Purity: At least 97% by TLC
λmax:No UV adsorption
Melting point175C-185C
Solubility

Clear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml methanol

Storage-20°C.
ApplicationsResiniferatoxin has been used to label the vanilloid receptor in sensory ganglia.
Resiniferatoxin activates protein kinase C.
  
WarningsToxic. Irritant.
Classificationditerpene
vanilloid receptoractivator
PKC activator
Related products 
 For Research use only. Not for Human or Drug use
GMP/API grade available on request.
Plant extract.
Resiniferatoxin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
Publications 
  John K Neubert, Andrew J, Mannes, Laszlo J, Karai, Alan C, Jenkins, Lanel Zawatski, Mones Abu-Asab, Michael J Iadarola
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
Molecular Pain 2008, 4:3
 Tang W, Song B, Zhou ZS, Lu GS.
Chin Med J (Engl). 2007 Sep 20;120(18):1616-21.
Intrathecal administration of resiniferatoxin produces analgesia against prostatodynia in rats.




Euphorbia resinifera


Resiniferatoxin on Wikipedia



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