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Shohat B, Shaltiel A, Ben-Bassat M, Joshua H.
Cancer Lett. 1976 Nov;2(2):71-7.
The effect of withaferin A
on the fine structure of S-180 tumor cells.
Mouse sarcoma 180 (S-180) solid and ascites tumor cells were treated in vivo
and in vitro with withaferin A and observed with the electron microscope. The
compound was found to effect this spindle microtubules of cells in metaphase. An
interesting finding was the double membranes surrounding the chromosomes in the
treated cells; probably the nuclei were reconstructed directly from the
metaphase stage in the in vivo withaferin A-treated cells. In addition the
membranes of the cells in interphase were affected by in vivo or in vitro
treatment with the compound.
PMID: 1016961
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