|
Shohat B, Kirson I, Lavie D
Biomedicine. 1978 Jan-Feb;28(1):18-24
Immunosuppressive activity
of withaferin A and withanolide E.
Withaferin A and withanolide E, two steroidal lactones of plant origin were
demonstrated to have specific immunosuppressive effects on human B and T
lymphocytes as well as on mice thymocytes. E rosettes and EAC rosette formation
by normal human T and B lymphocytes were inhibited by the two compounds at very
low concentrations. The formation of mouse red blood rosettes by chronic
lymphatic leukemic cells were only inhibited by withaferin A. The functional
activity of normal human T lymphocytes as assessed by a local xenogeneic graft
versus host reaction was also affected by these two plant steroidal lactones.
These experiments demonstrate a specific action of the compound on antigen
recognition as well as proliferative capacity of T lymphocytes as well as B
lymphocytes
PMID: 27256
|
