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Rosazza JP, Nicholas AW, Gustafson ME.
Steroids. 1978 May;31(5):671-9.
Microbial transformations of
natural antitumor agents. 7. 14-alpha-Hydroxylation of withaferin-A by
Cunninghamella elegans (NRRL 1393).
Microbial transformation experiments were conducted with the steroidlactone,
withaferin-A (1a). Cunninghamella elegans (NRRL 1393) converts withaferin-A into
two major metabolites, one of which has been indentified as
14alpha-hydroxywithaferin-A (1b). The metabolite is obtained in 37% yield, and
its structure was determined on the basis of pmr and mass spectral evidence. The
metabolite has the same level of antitumor activity as withaferin-A against the
Sarcoma-180 tumor test system in mice
PMID: 675739
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