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Devi PU, Sharada AC, Solomon FE.
Cancer Lett. 1995 Aug 16;95(1-2):189-93
In vivo growth inhibitory
and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma.
Department of Radiobiology, Kasturba Medical College, Karnataka, India.
Adult Swiss albino mice were inoculated intraperitoneally (i.p.) with 10 (6)
Ehrlich ascites carcinoma cells. Twenty-four hours later they were given an i.p.
injection of 10-60 mg/kg of withaferin A (WA), isolated from the roots of
Withania somnifera. The tumor growth and tumor free animal survival were studied
for up to 120 days. In another experiment 30 mg/kg WA was injected i.p. to mice
at 1, 3 or 5 days after tumor cell injection with or without acute abdominal
exposure to 7.5 Gy gamma radiation and the tumor growth and 120-day survival
were studied. WA inhibited tumor growth and increased tumor free survival in a
dose-dependent manner. The drug ED50 for 120-day survival was approximately 30
mg/kg body wt. Drug treatment before irradiation synergistically increased
120-day even in advanced tumors. A dose of 30 mg/kg seems to be optimum for
combination with radiation.
PMID: 7656229
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