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Horikawa K, Oishi N, Nakagawa J, Kasai A, Hayakawa K,
Hiramatsu N, Takano Y, Yokouchi M, Yao J, Kitamura M.
Novel potential of tunicamycin as an activator of the aryl
hydrocarbon receptor -- dioxin responsive element signaling
pathway.
FEBS Lett. 2006 Jun 26;580(15):3721-5.
Department of Molecular Signaling, Interdisciplinary Graduate
School of Medicine and Engineering, University of Yamanashi,
Chuo, Yamanashi 409-3898, Japan.
Tunicamycin is a well-known inhibitor of protein glycosylation
and used as an inducer of endoplasmic reticulum (ER) stress. We
found that tunicamycin induced expression of cytochrome P450 1A1
in a dose-dependent manner. Like dioxin, the transcriptional
induction was associated with dose-dependent activation of the
dioxin responsive element (DRE). This effect was independent of
inhibition of protein glycosylation or induction of ER stress.
Pharmacological and genetic inhibition of the aryl hydrocarbon
receptor (AhR) significantly attenuated activation of DRE by
tunicamycin. These results elucidated the novel potential of
tunicamycin as an activator of the AhR -- DRE signaling pathway.
PMID: 16765953
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