Oh-ishi S, Yamaki K, Abe M, Tomoda H, Omura S.The acyl-CoA
synthetase inhibitor triacsin C enhanced eicosanoid release in
leukocytes.
Jpn J Pharmacol. 1992 Jul;59(3):417-8.
Department of Pharmacology, School of Pharmaceutical
Sciences, Kitasato University, Tokyo, Japan.
Triacsin C was previously reported to inhibit long-chain
acyl-CoA synthetase and to reduce the production of acyl-CoA in
rat neutrophils dose- and time-dependently. We found that
preincubation with triacsin C inhibited the incorporation of
labeled arachidonic acid into rat neutrophils. Furthermore, when
triacsin C-treated neutrophils were stimulated with the
Ca-ionophore A23187, they released an increased amount of
eicosanoids into the culture medium. These results indicate that
triacsin C suppressed acylation of arachidonic acid, which
resulted in an increase in its metabolites.
PMID: 1434135
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