Sugiyama K, Arakawa K, Satoh H, Saito K, Takahashi K, Saito N,
Hirano T.Correlation between pharmacological efficacy of
cyclosporine A and Tacrolimus , evaluated by lymphocyte
immunosuppressant-sensitivity test (LIST) with MTT assay
procedure in renal transplant recipients.
J Immunoassay Immunochem. 2006;27(2):195-205.
Division of Pharmacy, Niigata University Medical and Dental
Hospital, Niigata City, Niigata, Japan.
sugiyama-nii@umin.ac.jp
The dose of calcineurin inhibitors in renal transplantation has
been adjusted, based on the therapeutic drug monitoring data.
However, the data do not always correlate with clinical drug
efficacy. In vitro response of peripheral-blood mononuclear
cells to immunosuppressive drugs is reported to correlate with
the recipient-response to therapeutic efficacy of the drug. We
report, here, usefulness of a lymphocyte immunosuppressant
sensitivity test for the estimation of individual drug
sensitivity in renal transplant recipients. The LIST we have
developed includes MTT assay procedures without the use of
radioisotope-labeled compounds, which is convenient for general
hospital use. Utilizing this procedure, we compared the
pharmacological efficacy between cyclosporine A and tacrolimus
in 41 renal transplant recipients.
PMID: 16711256
|
