Laeijendecker R, Tank B, Dekker SK, Neumann HA.A comparison
of treatment of oral lichen planus with topical Tacrolimus
and triamcinolone acetonide ointment.
Acta Derm Venereol. 2006;86(3):227-9
Department of Dermatology, Albert Schweitzer Hospital,
Dordrecht, The Netherlands.
R.Laeijendecker@asz.nl
Treatment of symptomatic oral lichen planus remains a
challenging problem. This study compared the efficacy of topical
tacrolimus ointment with triamcinolone acetonide ointment in
patients with oral lichen planus. Twenty patients (group I) were
treated with topical tacrolimus 0.1% ointment 4 times daily, and
20 (group II) were treated with triamcinolone acetonide 0.1%
ointment 4 times daily. The clinical effect was graded after 6
weeks. In group I, 6 patients healed, 12 showed improvement and
2 showed no improvement. In group II, 2 patients healed, 7
improved and 11 showed no improvement. The most commonly
reported side-effect in both groups was temporary burning or
stinging at the site of application. Unfortunately, oral lesions
recurred within 3-9 weeks of cessation of treatment in 13 of the
18 patients who had initially shown an improvement or were
healed in group I and in 7 of the 9 patients in group II.
Topical tacrolimus 0.1% ointment induced a better initial
therapeutic response than triamcinolone acetonide 0.1% ointment.
However, relapses occurred frequently within 3-9 weeks of the
cessation of treatment.
PMID: 16710580
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