Kino T, Hatanaka H, Hashimoto M et al.
tacrolimus, a novel immunosuppressant isolated from a
Streptomyces. I. Fermentation, isolation, and physicochemical
and biological characteristics.
J Antibiot (Tokyo) 1987; 40: 1249–1255.
Exploratory Research Laboratories, Fujisawa Pharmaceutical
Co., Ltd., Ibaraki, Japan.
FK-506, a novel immunosuppressant, has been isolated from the
fermentation broth of Streptomyces tsukubaenis No. 9993 as
colorless prism and the molecular formula was determined as
C44H69NO12.H2O. The compound suppressed immune responses in
vitro and in vivo with mice. This immunosuppressive effect was
more potent than that of ciclosporin.
PMID: 2445721
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