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Liu Y
Kidney Int. 2006 Jun;69(11):1925-7 Comment on: Kidney Int. 2006
Jun;69(11):2029-36.
Rapamycin and chronic kidney disease: beyond the inhibition of
inflammation.
Division of Cellular and Molecular Pathology, Department of
Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
15261, USA. liuy@upmc.edu
Rapamycin, a potent inhibitor of the mammalian
target of rapamycin (mTOR) protein kinase, is a well-known
immunosuppressive agent. In this issue, Wu and colleagues report
that rapamycin significantly attenuates renal interstitial
fibrosis in obstructive nephropathy. Besides its inhibition of
renal inflammation, rapamycin is able to block tubular
epithelial-mesenchymal transition, thereby shedding new light on
the mechanism of its antifibrotic actions.
PMID: 16724087
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