A Nakamura, K Nagai, K Ando, G TamuraSelective suppression
by prodigiosin of the mitogenic response of murine splenocytes.
J Antibiot (Tokyo). 1986 Aug ;39 (8):1155-9
In the course of screening for immunomodulating substances
among microbial metabolites using a triple mitogen assay system,
we detected an immunosuppressive activity which is similar to
cyclosporin A. Two active components were isolated as red
pigments from the fermentation broth of Streptomyces
hiroshimensis and they were identified with prodigiosin 25-C and
metacycloprodigiosin respectively. These compounds inhibited T
lymphocyte proliferation which was induced by plant lectins,
concanavalin A (Con A) and phytohemagglutinin (PHA), much more
extensively than B lymphocyte proliferation which was induced by
lipopolysaccharide (LPS). Prodigiosin 25-C completely inhibited
induction of cytotoxic T cells in a mixed lymphocyte reaction (MLR)
at 4 ng/ml.Mesh-terms:
Animals; Concanavalin A :: pharmacology; Immunosuppressive
Agents :: pharmacology; Lymphocyte Activation :: drug effects;
Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C;
Mice, Inbred C57BL; Prodigiosin :: isolation & purification;
Prodigiosin :: pharmacology; Spleen :: drug effects;
ST-Lymphocytes, Cytotoxic :: drug effects; |
