Janse van Rensburg DF, Thiel PG, Jaskiewicz K.Short-term
effects of two fusarium toxins, diacetoxyscirpenol and
neosolaniol monoacetate, in male Wistar rats.
Food Chem Toxicol. 1987 Oct;25(10):767-71.
Research Institute for Nutritional Diseases, South African
Medical Research Council, Tygerberg.
This study compared the pathological and haematological
effects of neosolaniol monoacetate in male Wistar rats with
those of diacetoxyscirpenol, a highly toxic trichothecene
mycotoxin. Both toxins caused statistically significant
decreases in erythrocyte counts and increased the proportion of
larger platelets compared to controls when dosed at 1 mg/kg body
weight three times/wk for up to 5 wk. Lesions caused by
treatment with either toxin at this dosage level were mild and
were seen--mainly after 2-4 wk--in the actively dividing cells
of the thymus, spleen, lymph nodes and bone marrow. Reduced
severity or disappearance of the lesions was noted towards the
end of the treatment period. The type and severity of the toxic
effects of neosolaniol monoacetate appeared to be similar to
those of diacetoxyscirpenol.
PMID: 3679023 |
