Harvey B, Edrington TS, Kubena LF,
Rottinghaus GE, Turk JR, Genovese KJ, Ziprin RL, Nisbet DJ.
Toxicity of fumonisin from Fusarium
verticillioides culture material and moniliformin from Fusarium
fujikuroi culture material when fed singly and in combination to
growing barrows.
J Food Prot. 2002 Feb;65(2):373-7.
Food and Feed Safety Research Unit, Southern Plains Area
Research Center, Agricultural Research Service, US Department of
Agriculture, College Station, Texas 77845, USA.
harvey@ffsru.tamu.edu
The effects of fumonisin B1 (FB1) from Fasarium verticillioides
culture material and moniliformin from Fusarum fujikuroi culture
material on growing barrows were evaluated. Four groups of six
barrows (three replicates of two each; mean body weight, 11.1
kg) were fed diets containing 0 mg of FB1 and 0 mg of
moniliformin per kg of feed (control), 100 mg of FB1 per kg of
feed, 100 mg of moniliformin per kg of feed, and 100 mg of FB1
plus 100 mg of moniliformin per kg of feed. Barrows were fed
these diets for 28 days. Body weight gain, feed efficiency,
serum biochemical analytes, and hematological values were
adversely affected by the FB1 and the FB1-plus-moniliformin
diets. The moniliformin diet decreased body weight gain. Two
barrows in the moniliformin diet group died, and two barrows in
the FB1-plus-moniliformin diet group died. All deaths occurred
during the first 6 days of the study. Mild to moderate lesions
were observed microscopically in heart and lung tissues of the
groups fed moniliformin and FB1 plus moniliformin and in liver
tissues of the groups fed FB1 and FB1 plus moniliformin. Except
for the acute mortality associated with the two diets containing
moniliformin. clinical disease induced by the combined feeding
of these two mycotoxins appears to be additive or less than
additive and due primarily to the toxic expression of FB1.
PMID: 11848570
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