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Tamaki K, Shotwell JB, White RD, Drutu I, Petsch DT, Nheu TV, He H, Hirokawa Y,
Maruta H, Wood JL.
Efficient syntheses of novel C2'-alkylated (+/-)- K252a analogues.
Org Lett. 2001 May 31;3(11):1689-92.
Sterling Chemistry Laboratory, Department of Chemistry, Yale
University, New Haven, Connecticut 06520-8107, USA
Recent efforts in our laboratories have resulted in a
synthetic approach toward C2'-alkylated K252a analogues via
extension of a K252a cyclofuranosylation strategy. The
bis-indole-N-glycosidic coupling of
6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of
highly functionalized carbohydrates has given access to
previously unattainable, biologically relevant analogues
PMID: 11405687 |
