Lee HW, Cho CS, Kang SK, Yoo YS, Shin JS, Ahn SK.
Design, synthesis, and antiangiogenic effects
of a series of potent novel fumagillin analogues.
Chem Pharm Bull (Tokyo). 2007 Jul;55(7):1024-9.
New Drug Research Laboratories, Chong Kun Dang Research
Institute, Cheonan, South Korea.
hwlee@ckdpharm.com
A series of fumagillin analogues containing the
C6-substituted cinnamoyl moiety were designed, synthesized, and
evaluated for antiangiogenic activity. Among them,
4-hydroxyethoxy-cinnamoyl fumagillol (4a) and
4-hydroxyethoxy-3,5-dimethoxycinnamoyl fumagillol (4d) exhibited
more potent anti-proliferation activity in CPAE and HUVEC cells
with low cytotoxicity in vitro. These compounds are presently
under further pharmacological evaluation studies.
PMID: 17603194 |
