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Rosenstein Y, Lafarge-Frayssinet C, Lespinats G,
Loisillier F, Lafont P, Frayssinet C.
Immunology. 1979
Jan;36(1):111-7.
Immunosuppressive activity of
Fusarium toxins. Effects on antibody synthesis and skin grafts
of crude extracts, T2-toxin and diacetoxyscirpenol.
The inhibitory effect of crude Fusarium poae extracts, T2-toxin
and diacetoxyscirpenol on synthesis of antibody to sheep red
blood cells was investigated, as well as the effect of T2-toxin
on skin graft rejection. Fusarium crude extracts, T2-toxin and
diacetoxyscirpenol cause a significant reduction in thymus
weight and inhibit responsiveness to sheep red blood cells. The
effect on antibody synthesis was critically dependent on the
drug doses used. The effect of an immunosuppressive dose of
T2-toxin disappeared within 6 days after the end of the
treatment. The administration of T2-toxin subsequent to
immunization stops antibody synthesis. T2-toxin significantly
prolongs the period required for skin graft rejection.
PMID: 369993 [PubMed - indexed for MEDLINE]
PMCID: PMC1457389
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