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Mizuno S. Biochim Biophys Acta. 1975 Mar 10;383(2):207-14
Mechanism of inhbition of protein systhesis initiation by
diacetoxyscirpenol and fusarenon X in the reticulocyte lysate
system.
The mechanism of inhibition of peptide chain initiation by
diacetoxyscirpenol and fusarenon X, (trichotecene mycotoxins),
was studied in the reticulocyte lysate protein-synthesizing
system. The mycotoxins did not inhibit formation of the complex
between Met-tRNA-f and the 40S ribosomal subunit nor the
initiation codon AUG-promoted combination of the complex with
60S ribosomal subunit. Formyl-methionyl-valine accumulated when
the system was incubated with the mycotoxins and fMet-tRNA-f.
This suggests that the inhibition occurs after the formation of
the first peptide bond.
PMID: 1120165 |
