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Claridge CA, Schmitz H, Bradner WT.
Cancer Chemother Pharmacol. 1979;2(3):181-2.
Antitumor activity of some microbial and chemical
transformation products of anguidine (4,15-diacetoxyscirpenol).
The in vivo antitumor activities, as measured by
inhibition of transplanted P-388 and L-1210 leukemia in mice,
have been determined for a series of analogs of anguidine
including triacetoxyscirpenol, the three diacetoxyscirpenols,
the three monoacetoxyscirpenols, and scirpenetriol. An acetoxy
function at position 15 appears to be required for good
activity.
PMID: 455572 |
