Sobolev VSDetermination of ionization constant
(pKa) and octanol-water partition coefficient (Log P) of
cyclopiazonic acid.
J AOAC Int. 2005 Sep-Oct;88(5):1367-70.
U.S. Department of Agriculture, Agricultural Research
Service, National Peanut Research Laboratory, P.O. Box 509,
Dawson, GA 39842, USA. vsobolev@nprl.usda.gov
The ionization constant (pKa) and the octanol-water partition
coefficient (log P) of the important mycotoxin cyclopiazonic
acid (CPA) were determined by means of potentiometric titration,
and the lipophilicity profile (log D) was calculated. Under the
experimental conditions, pKa of CPA = 2.97 +/- 0.09, log P =
3.83 +/- 0.10, and log D at pH 7.4 = -0.58.
PMID: 16385984
|
