Keblys M, Bernhoft A, Hofer CC, Morrison E, Larsen HJ, Flaoyen
A.The effects of the Penicillium mycotoxins citrinin,
cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and
roquefortine C on in vitro proliferation of porcine lymphocytes.
Mycopathologia. 2004 Oct;158(3):317-24.
National Veterinary Institute, P.O. Box
8156 Dep., N-0033, Oslo, Norway.
The in vitro effect of each of the
Penicillium mycotoxins citrinin (CIT),
cyclopiazonic acid (CPA), ochratoxin A
(OTA), patulin (PAT), penicillic acid (PIA)
and roquefortine C (RQC) on mitogen induced
lymphocyte proliferation was determined
using purified lymphocytes from 6 piglets.
Dose response curves for each mycotoxin were
generated and the concentrations producing
50% inhibition of cell proliferation
(IC(50)) were estimated. OTA and PAT were
the most potent toxins with IC(50) of 1.3
and 1.2 micromol/l, respectively (0.52 and
0.18 mg/l, respectively). Based on molar
concentrations, OTA was 15, 30, 40, and 65
times more potent as an inhibitor than PIA,
CIT, CPA and RQC, respectively.
PMID: 15702270
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