Kamalavenkatesh P, Vairamuthu S, Balachandran C, Manohar BM, raj
GD.Immunopathological effect of the mycotoxins cyclopiazonic
acid and T-2 toxin on broiler chicken.
Mycopathologia. 2005 Feb;159(2):273-9.
Toxicology Department, Jai Research Foundation, Valvada, 396
108, India.
Forty, newly hatched, unsexed broiler chicks were fed diets
containing 10 ppm cyclopiazonic acid (CPA) and 1 ppm T-2 toxin
(T2) either individually or in combination for 28 days to study
the immunopathological effects. Lymphoid organs revealed
lymphocytolysis and lymphoid depletion in all toxin fed birds.
Thymic and splenic CD+4 and CD+8 lymphocytes decreased
significantly (p<0.01) in toxin fed birds when compared to the
control. Thymic CD+8 lymphocytes of T2 and CPA-T2 showed
significant (p<0.01) decrease from that of CPA and control
groups. Splenic CD+4 and CD+8 lymphocytes showed significant
(p<0.01) decrease in CPA and CPA-T2 fed groups when compared to
the control. The T2 group did not differ significantly from that
of control. The stimulation index (SI) of splenocytes to
concavalin A revealed significant (p<0.01) decrease in all toxin
fed birds. Significant (p<0.01) decrease were observed for the
haemagglutination inhibition (HI) titres to Newcastle disease
virus vaccine F strain (NDV) of birds fed CPA, T2 and in
combination. Significant (p<0.01) interaction was found for
lymphocyte subsets, SI and HI titres to NDV. The study indicated
the immunosuppressive effect of these toxins either alone or in
combination in broiler chicks.
PMID: 15770454
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