|
Singh ND, Sharma AK, Dwivedi P, Patil RD, Kumar M.
Citrinin and
endosulfan induced maternal toxicity in pregnant Wistar rats:
pathomorphological study.
J Appl Toxicol. 2007 Apr 11
Division of Pathology, Indian Veterinary Research Institute,
Izatnagar 243122, India.
Dietary exposures to environmental food pollutants such as
mycotoxin(s) or pesticide(s) have gained immense significance
due to their adverse effects on production and reproduction in
animal and human populations. The present investigation was
conducted to evaluate the maternal toxicity of citrinin (CIT)
and endosulfan administered per os either alone or in
combination in pregnant rats during gestational days 6-20. CIT
(group I, 10 mg kg(-1) feed, through diet) and endosulfan (group
II, 1 mg kg(-1) body weight, by oral intubation) when
administered either alone or in combination (group III) in
Wistar rats caused clinical signs of toxicity and
pathomorphological changes in all the toxin treated groups, the
severity being more pronounced in the combination treatment
compared with that observed in the control (group IV). The rate
of fetal resorptions was highest (22.22%) in the combination
treatment followed by endosulfan (16.48%) and CIT (12.50%)
treatment groups compared with the control group (3.86%). The
histopathological changes such as engorged vasculature, vacuolar
degeneration and karyomegaly in liver; congestion, tubular
degeneration and cast formation in kidneys; vascular changes and
hemosiderosis in uterus and lymphocytic depletion and apoptosis
in the lymphoid organs were recorded in the animals of the toxin
treated groups. The lesions were consistent and more severe in
the combination treatment group compared with the individual
treatment groups, suggesting an additive interaction of CIT and
endosulfan in inducing maternal toxicity in Wistar rats.
Copyright (c) 2007 John Wiley & Sons, Ltd.
PMID: 17429798 ZZZ from Fermentek for sale
|
