|
Chan WH, Shiao NH.
Effect of
citrinin on mouse embryonic development in vitro and in vivo.
Reprod Toxicol. 2007 May 10
Department of Bioscience Technology and
Center for Nanotechnology, Chung Yuan Christian University,
Chung Li, Taiwan; R&D Center for Membrane Technology, Chung Yuan
Christian University, Chung Li, Taiwan.
Citrinin , a mycotoxin that is often found
as a natural contaminant in foodstuffs and animal feeds, has
been demonstrated to have cytotoxic and genotoxic effects on
various mammalian cells. In this study, we examined the
cytotoxic effects of Citrinin on mouse blastocysts and
subsequent early development in vitro and in vivo. Blastocysts
treated with 15 or 30muM Citrinin showed significant
increases in apoptosis and significant decreases in total cell
number. In addition, Citrinin -pretreated blastocysts showed a
significantly lower implantation success rate. Treatment with
30muM Citrinin was associated with increased resorption of
postimplantation embryos and decreased fetal weight. Our results
collectively indicate that Citrinin -induced apoptosis in the
mouse blastocyst reduced cell number and retarded early
postimplantation development. The extent to which Citrinin
may have teratogenic potential in early human development is not
known.
PMID: 17572064 |
