Bai LP, Zhao ZZ, Cai Z, Jiang ZH.Site-specific binding of
chelerythrine to single cytosine and thymine bulges in DNA
hairpins.
Nucleic Acids Symp Ser (Oxf). 2006;(50):197-8
School of Chinese Medicine, Hong Kong Baptist University,
Hong Kong.
Chelerythrine exhibits pronounced antitumor and apoptosis
activities. In order to provide insights into the molecular
mechanism of its pharmacological effects, binding selectivity of
chelerythrine to a series of single-base bulged DNA hairpins has
been assayed by using spectrofluorometric technique. The results
indicated that chelerythrine binds specifically to C- and
T-bulge sites in DNA hairpins, while sanguinarine exhibits
extremely weak binding selectivity to any single-base bulged DNA
hairpins, although it has very similar structure with
chelerythrine.
PMID: 17150885 |
