Emanuele Papini, Marina de Bernard, Massimo Bugnoli, Elisabetta
Milia, Rino Rappuoli, Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori:
Inhibition by bafilomycins A1, B1, C1 and D
FEMS Microbiology Letters 113 (2) , 155–159
All available bafilomycins (A1, B1, C1 and D) inhibit and
revert macroscopic vacuolization induced by Helicobacter
pylori cell-free extracts. Bafilomycin A1 displays the
highest activity, followed by bafilomycin B1, C1 and D. The
different potency of bafilomycins correlates with their ability
to inhibit the vacuolar-type ATPase (V-ATPase) and to dissipate
the membrane pH gradient of intracellular acidic organelles.
These results suggest that bafilomycins should be considered as
possible therapeutic agents in the treatment of gastritis. |
