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Staubli U, Faraday R, Lynch G.
Pharmacological
dissociation of memory: anisomycin, a protein synthesis inhibitor, and
leupeptin, a protease inhibitor, block different learning tasks.
Behav Neural Biol. 1985 May;43(3):287-97.
Inhibition of protein synthesis by anisomycin for a short
duration impairs memory of a one-trial inhibitory avoidance task
in rats. Memory of escape conditioning involving eight trials is
disrupted only if the duration of protein synthesis is prolonged
by repeated injections. In marked contrast, olfactory memory of
rats trained on two odor discriminations is not affected by
anisomycin even if the duration of inhibition is prolonged and
the number of trials is reduced to a minimum. In previous work,
leupeptin, a thiol proteinase inhibitor, was shown to impair
olfactory discrimination learning, but left inhibitory and
avoidance conditioning intact. Together, these results provide a
pharmacological double dissociation of memory, and suggest that
the same chemistries, or mixtures of chemistries, may not be
involved in all types of memory.
PMID: 3842251 |
