|
Butera PC, Campbell RB, Bradway DM.
Antagonism of
estrogenic effects on feeding behavior by central implants of anisomycin.
Brain Res. 1993 Oct 8;624(1-2):354-6.
Department of Psychology, Niagara University, NY 14109.
The following experiment determined whether the estrogenic
suppression of food intake is dependent upon changes in protein
synthesis within neurons of the paraventricular nucleus of the
hypothalamus (PVN). Ovariectomized rats were treated centrally
with anisomycin-filled or empty (control) cannulae in the PVN.
Females were injected with either 2.0 micrograms of estradiol
benzoate (EB) or the oil vehicle and the inner cannulae were
removed 2 h later. EB injections significantly lowered food and
water intake in the central control group but not in animals
given PVN implants of anisomycin. Body weight gain decreased for
all females. EB induced comparable levels of female sexual
behavior in both groups, demonstrating that anisomycin implants
did not affect the ability of estradiol to stimulate lordosis.
These findings indicate that the effects of estradiol on food
intake require the activation of protein synthesis in
estrogen-sensitive PVN neurons.
|
