Woolley GA.Channel-forming activity of alamethicin: effects
of covalent tethering.
Chem Biodivers. 2007 Jun;4(6):1323-37.
Department of Chemistry, University of Toronto, Toronto, ON,
Canada. awoolley@chem.utoronto.ca
In this short review article, the effects of covalent tethering
of alamethicin molecules on channel-forming behavior are
described. Broadly speaking, these chemical modifications have
provided insight into all three aspects of channel behavior: the
structure of the conducting state, the ion-selectivity and
ion-permeation properties, and the voltage dependence. Each of
these aspects are discussed in turn.
PMID: 17589884
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