Roebuck BD, Siegel WG, Wogan GN.In vitro metabolism of
aflatoxin B2 by animal and human liver.
Cancer Res. 1978 Apr;38(4):999-1002.
The metabolism of aflatoxin B2 by postmitochondrial
supernatant fractions of duck, rat, mouse, and human livers was
studied in an in vitro system. Duck liver had a much higher
level of activity than had tissues from other species.
Postmitochondrial supernatant equivalent to 0.2 g whole liver
metabolized 40 to 80% of the initial substrate in 30 min,
compared to less than 6% for the other species. Among several
metabolites formed by duck liver, aflatoxin B1 was produced in
amounts equivalent to 2 to 8% of the initial substrate, and
metabolites having chromatographic properties postualted for
aflatoxicols 1 and 2 and aflatoxins M1 and M2 were also formed
in small amounts. In contrast, rat, mouse, and human liver
preparations produced no detectable aflatoxin B1 and only small
amounts of compounds thought to be aflatoxins Q2 and P2. The
greater susceptibility of duck liver to the toxicity of
aflatoxin B2 may be attributable to its ability to form
aflatoxin B2 may be attributable to its ability to form
aflatoxin B1, which could then be activated through further
metabolism.
PMID: 639051
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