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Polychronaki N, West RM, Turner PC, Amra H, Abdel-Wahhab M,
Mykkanen H, El-Nezami H.
A longitudinal assessment of Aflatoxin M1
excretion in breast milk of selected Egyptian mothers.
Food Chem Toxicol. 2007 Jul;45(7):1210-5.
Department of Public Health and Clinical Nutrition,
University of Kuopio, Finland.
nektaria.polychronaki@uku.fi
Aflatoxins are potent toxins and carcinogens which can be
excreted in the milk of exposed lactating mothers mainly in the
form of Aflatoxin M1 . We previously evaluated the level and
frequency of Aflatoxin M1 in breast milk in a group of
Egyptian mothers attending the New El-Qalyub Hospital,
Qalyubiyah governorate, Egypt. In this study, fifty of those
women who were Aflatoxin M1 positive were revisited
monthly for 12 months to assess the temporal variation in breast
milk Aflatoxin M1 . Aflatoxin M1 was detected in 248 of
443 (56%) samples. In a multilevel model of the data there was a
highly significant (p<0.001) effect of month of sampling on the
frequency of Aflatoxin M1 detection with summer months
having the highest frequency (>80%) and winter months the lowest
frequency (<20%) of detection. Aflatoxin M1 was observed
most frequently in June [OR 63, 95% CI (7.6, 522)]. The level of
Aflatoxin M1 detection also followed this seasonal pattern
with highest mean level in July (64 pg/ml milk, range 6.3-497
pg/ml milk) and the lowest mean level in January (8 pg/ml milk,
range 4.2-108 pg/ml milk). The duration of lactation [p=0.0035,
OR=1.08, 95% CI (1.02, 1.13)], and peanut consumption [p=0.06,
OR=1.69, 95% CI (0.9, 2.9)] also contributed to the model. The
identification and understanding of factors determining the
presence of toxicants in human milk is important and may provide
a knowledge driven basis for controlling the transfer of
chemicals to infants.
PMID: 17306915
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