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Wyatt TA, Pryzwansky KB, Lincoln TM. Res Commun Chem Pathol
Pharmacol. 1991 Oct;74(1):3-14
KT5823 activates human neutrophils and fails to inhibit cGMP-dependent
protein kinase phosphorylation of vimentin.
Wyatt TA, Pryzwansky KB, Lincoln TM.
Department of Pathology, University of North Carolina, Chapel
Hill 27599-7525.
The effectiveness of the cGMP-dependent protein kinase
inhibitor, KT5823, was investigated in human neutrophils. KT5823
did not inhibit the cGMP-dependent protein kinase mediated in
vitro, or in situ phosphorylation of vimentin, a known substrate
for this enzyme in activated neutrophils. In addition, KT5823
was shown to induce dramatic shape changes in neutrophils,
suggesting it has an activating effect upon the cells.
PMID: 1666198 |
