Nakanishi S, Matsuda Y, Iwahashi K, Kase H.K252b, K252c and
K252d, potent inhibitors of protein kinase C from microbial
origin.
"The Journal of antibiotics." - J Antibiot (Tokyo).1986
Aug;39(8):1066-71
Nakanishi S, Matsuda Y, Iwahashi K, Kase H.Nocardiopsis sp.
K-290 was found to produce novel metabolites, designated K252b,
K252c and K252d, which were structurally related to K252a. These
compounds were isolated from the culture broth and the
physico-chemical and biochemical properties were examined. The
compounds strongly inhibited protein kinase C. IC50 values (the
concentrations causing 50% inhibition) for the effects of K252b,
K252c and K252d on the rat brain enzyme were 38.3, 214, and 337
nM, respectively.
PMID: 3759658
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