Tsuboi H, Yonemoto K, Katsuoka K.A 14-year-old girl with
lichenoid sarcoidosis successfully treated with FK506.
J Dermatol. 2006 May;33(5):344-8
Department of Dermatology, Kitasato University School of
Medicine, Sagamihara, Japan.
derma-10@yokomamc.hop.go.jp
We report a case of lichenoid sarcoidosis in a young girl
treated by oral tacrolimus and methylprednisolone. The patient
had had a skin eruption from 1 year of age and had developed
uveitis at 2 years of age. Her sight had become affected by the
uveitis at 8 years of age. When she was 14, she was admitted to
the ophthalmology department of our hospital to start treatment
with tacrolimus (FK506). She was referred to the department of
dermatology for her skin lesions, which were flat, pinkish or
normal skin-colored papules scattered on her extremities and the
backs of her hands. Upon histology, epithelioid granulomas were
seen in the upper dermis and around the erector pili muscles.
She received tacrolimus (FK506) 6 mg/day for 3 months for her
uveitis. The eye lesions subsided somewhat, and the skin lesions
were almost healed after the 3-month course of tacrolimus.
However, 4 months after stopping the tacrolimus, her skin and
eye lesions relapsed. At that point, she was started on
methylprednisolone 16 mg/day for her uveitis. With the
methylprednisolone treatment, the inflammation of the eye lesion
immediately healed, as did the skin lesions.
PMID: 16700667 |
