Shah S, Budev M, Blazey H, Fairbanks K, Mehta A.Hepatic
veno-occlusive disease due to Tacrolimus (FK506) in a
single-lung transplant patient.
Eur Respir J. 2006 May;27(5):1066-8.
Dept of Pulmonary, Allergy and Critical Care, Cleveland
Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Hepatic veno-occlusive disease is defined as nonthrombotic
fibrous obliterative endophlebitis of small centrilobular
hepatic venules. Clinically, patients present with elevated
liver enzymes and a triad of jaundice, hepatomegaly and ascites.
Although reported as a complication of other solid organ and
stem cell transplantation, there have been no reported cases to
date of veno-occlusive disease following lung transplantation.
The present authors report a case of veno-occlusive disease
following single-lung transplantation in a patient on a
triple-drug immunosuppressive regimen composed of tacrolimus,
mycophenolate mofetil and prednisone. The diagnosis was
established by transjugular liver biopsy and by discontinuing
tacrolimus; there was clinical regression of symptoms and
serological return to baseline.
PMID: 16707401
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