Dotsch J, Dittrich K, Plank C, Rascher W.Is Tacrolimus
(FK506) for childhood steroid-dependent nephrotic syndrome
better than ciclosporin A?
Nephrol Dial Transplant. 2006 May 15
There is currently no rationale for the use of TAC in place of
CSA in children with SDNS and minimal change glomerulopathy,
bearing in mind that all the studies performed so far are
retrospective and based on a limited number of patients. In
addition, the risk of drug-induced IDDM during TAC treatment of
SDNS is rather discouraging.
In contrast, TAC might be more promising for the treatment of
SRNS, e.g. in patients with focal segmental glomerulosclerosis .
Studies in this field might, therefore, be more interesting.
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