| Source: | Humicola
grisea |
| Synonyms | Monorden |
| Description: | Radicicol is a macrolactone antibiotic. Radicicol is a tyrosine kinase inhibitor. It displays anti-angiogenic activity. |
| CAS number: | 12772-57-5 |
| Merck index: | 12, 6336 |
| Molecular weight: | 364.78 |
| Structure: | 
 |
| Molecular Formula: | C18H17ClO6 |
Solubility
information: | Methanol, Ethanol, DMSO |
| Specifications |
|
| Appearance: | Yellow powder |
| Purity: | At least 98% by TLC, HPLC |
| λmax: | 211,265 |
| Melting point | 190°C-194°C |
| Solubility | Clear colorless solution at 20mg/ml DMSO |
| Storage | -20°C. Protect from light. |
| Applications | |
| Warnings | Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. |
| Classification | macrolactone
tyrosine kinase inhibitor
angiogeniesis inhibitor
HSP90 inhibitor |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Radicicol by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Griffin TM, Valdez TV, Mestril R.
Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes.
Am J Physiol Heart Circ Physiol. 2004 Apr 29 |
| | Ikuina Y, Amishiro N, Miyata M, Narumi H, Ogawa H, Akiyama T, Shiotsu Y, Akinaga S, Murakata C.
Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.
J Med Chem. 2003 Jun 5;46(12):2534-41 |
| | Lee MO, Kim EO, Kwon HJ, Kim YM, Kang HJ, Kang H, Lee JE.
Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90
(HSP90).
Mol Cell Endocrinol. 2002 Feb 25;188(1-2):47-54 |
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Humicola fuscoatra
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