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cancer research reagents

Puromycin dihydrochloride

MSDSSample CoARaw materials from animal origin info
 
Source: Streptomyces alboniger
SynonymsStylomycin, P638, Puromycin
Description: Puromycin is a protein synthesis inhibitor. It causes premature chain termination
CAS number: 58-58-2
Merck index: 12, 8130
Molecular weight: 471.52
Structure:

Puromycin   structure

 

Molecular Formula: C22H29N7O52HCl
Canonical SMILES:  
Solubility
information:
 
Specifications 
Appearance: White powder
PurityAt least 98% by TLC, HPLC
λmax:275, 267
Melting point168°C-182°C
SolubilityClear, slightly brown solution at 50mg/ml of water
Storage+4°C.
ApplicationsPuromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase
Puromycin is also a Antineoplastic agent.
Puromycin possesses  antoprotozoal activities (against Trypanozoma)
WarningsTOXIC. POTENTIAL CARCINOGEN
ClassificationNucleoside antibiotic
Protein synthesis inhibitor
Related productsPuromycin Aminonucleoside
 For Research use only. Not for Human or Drug use
GMP/API grade
No genetically modified organisms are used.

Raw materials from animal origin info

Publications 
 Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui KS, Wiedau-Pazos M, Vinters HV, Binder LI, Geschwind DH, Jackson GR.
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
Neuron. 2006 Sep 7;51(5):549-60
 Abe M, Sato Y.
Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies.
Genes Cells. 2006 Jul;11(7):719-29.
 Iwaki T, Castellino FJ. 
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins.
Cytotechnology. 2008 May;57(1):45-9.
 Croons V, Martinet W, Herman AG, De Meyer GR.
Differential effect of the protein synthesis inhibitors puromycin and cycloheximide on vascular smooth muscle cell viability.
J Pharmacol Exp Ther. 2008 Jun;325(3):824-32.
 Vajda S, Bartha K, Wilhelm I, Krizbai IA, Adam-Vizi V.
Identification of protease-activated receptor-4 (PAR-4) in puromycin-purified brain capillary endothelial cells cultured on Matrigel.
Neurochem Int. 2008 May;52(6):1234-9
 Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC.
Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes.
Nephron Exp Nephrol. 2007;107(3):e87-94.
 


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