| Source: |
Serratia marcescens |
| Synonyms | *** do not
confuse with PRODIGIOZAN,
a polysaccharide antibiotic of similar source *** |
| Description: | Prodigiosin is an
antibiotic pigment produced by Serratia marcescens and several other
bacterial strains, such as Vibrio psychroerythrus, Streptomyces
griseoviridis, Hahella chejuensis.
Exhibits antimicrobial and cytotoxic
properties. |
| CAS number: | 82-89-3 |
| Merck index: | 14:7767 |
| Molecular weight: | 323.43 |
| Structure: | 
 |
| Molecular Formula: | C20H25N3O |
Solubility
information: | Prodigiosin
is almost insoluble in water. Moderately soluble in alcohols: ethanol,
methanol, ether, petroleum ether and hexane; freely sol in dichloromethane,
benzene, DMSO. Alkaline or neutral solutions are orange-yellow, acid
solutions are red |
| Specifications |
|
| Appearance: | Dark red crystalline solid. |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | in isopropanol: 466,
336, 280
in 0.1 N HCl in MeOH: 354
in 0.1 NaOH in Methanol: 467 |
| Melting point | 151°C-152°C |
| Solubility | Ethanol
Dichloromethane
DMSO |
| Storage | -18°C. |
| Applications | - Anti-microbial
-
Anti-malarial
- Anti-cancer
- Immunosuppressive.
|
| Warnings | |
| Classification | Pyrrole antibiotic |
| Related products | |
| | For Research use only.
Not for Human or Drug use
GMP/API grade available on request
Prodigiosin by Fermentek is not produced from or contains any ingredients
from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Pandey R, Chander R, Sainis KB.
Prodigiosin : a novel family of immunosuppressants with anti-cancer
activity.
Indian J Biochem Biophys. 2007 Oct;44(5):295-302. |
| | Soto-Cerrato V, Viñals F, Lambert
JR, Pérez-Tomás R.
The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via
transforming growth factor-beta receptor pathway.
Biochem Pharmacol.
2007 Nov 1;74(9):1340-9. |
| | Sang-Bae Han, Chang Woo Lee, Yeo
Dae Yoon, Jong Soon Kang, Ki Hoon Lee, Won Kee Yoon, Young Kook Kim, Kiho
Lee, Song-Kyu Park, Hwan Mook Kim
Effective prevention of lethal acute graft-versus-host disease by combined
immunosuppressive therapy with prodigiosin and cyclosporine A.
Biochem Pharmacol. 2005 Nov 15;70 (10):1518-26 |
| | A Nakamura, K Nagai, K Ando, G
Tamura
Selective
suppression by prodigiosin of the mitogenic response of murine
splenocytes.
J Antibiot (Tokyo). 1986 Aug ;39 (8):1155-9 |
| | B Montaner, S Navarro, M Piqué, M
Vilaseca, M Martinell, E Giralt, J Gil, R Pérez-Tomás
Prodigiosin from the supernatant of Serratia marcescens induces
apoptosis in haematopoietic cancer cell lines.
Br J Pharmacol. 2000
Oct ;131 (3):585-93 |
|
This product has been DISCONTINUED
in October 2010
|
|
Serratia marcescens
on agar
|
Prodigiosin on Wikipedia
|
|
|
