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cancer research reagents

PKC412 (Midostaurin)

MSDSSample CoA
 
Source: Semisynthetic derivate of Staurosporine.

Made from  Staurosporine  from Streptomyces staurosporeus

Synonyms Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251
Description: PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.
CAS number: 120685-11-2
Merck index: 14:6185
Molecular weight: 570.6
Structure:

PKC412 (Midostaurin)  for sale

 

Molecular Formula: C35H30N4O4
Canonical SMILES:  
Solubility
information:
Soluble in DMSO, Dichloromethanol
water solubility : < 0.1 mg/1
Specifications 
Appearance: White to off-white powder
Purity: Not less than 96% by HPLC, TLC

Current lot: 98.96% by HPLC

λmax:241, 292, 334, 370 nm
Melting point225-235ºC
SolubilityClear colorless solution at 10mg/ml DMSO / 10mg/ml MDC / 5mg/ml methanol
Storage-20ºC. Protect from moisture and direct light.
ApplicationsPKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)

PKC412 selectively inhibits protein kinase C (PKC),

Classification indolocarbazole alkaloid
PKC inhibitor
Warnings May be irritating to eyes, skin and respiratory system
Related products
 KT5853 ,  KT5720 ,  staurosporine ,  PKC412  

 K252a ,  K252B   K252c

 

 For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
PublicationsLi H, Hergert SM, Schäfer SC, Brausch I, Yao Y, Huang Q, Mang C, Lehr HA, Förstermann U.
Nitric Oxide. 2005 Jun;12(4):231-6.
Midostaurin (PKC412) upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse.
 Millward MJ, House C, Bowtell D, Webster L, Olver IN, Gore M, Copeman M, Lynch K, Yap A, Wang Y, Cohen PS, Zalcberg J.
Br J Cancer. 2006 Oct 9;95(7):829-34
The multikinase inhibitor midostaurin (PKC412) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study.
 Barry EV, Clark JJ, Cools J, Roesel J, Gilliland DG.
Blood. 2007 Dec 15;110(13):4476-9
Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin (PKC412).


 



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Antineoplastic, alkaloid;  PKC412 (Midostaurin) for sale at fermentek biochemicals; GMP, : Cell signalling tools