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cancer research reagents

Patulin

MSDSSample CoA
 
Source: Penicillium expansum
SynonymsClavacin,
Claviformin,
Mycoin C3
Description: Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.
CAS number: 149-29-1
Merck index: 12, 7185
Molecular weight: 154.1
Structure:

 

Molecular Formula: C7H6O4
Canonical SMILES: C1C=C2C(=CC(=O)O2)C(O1)O
Solubility
information:
Patulin is soluble in DMSO, Methanol, Ethanol, water
Specifications 
Appearance: White crystalline solid.
Purity: At least 98% by TLC, HPLC
λmax:276
Melting point105°C-111°C
SolubilityClear colorless solution at 10mg of Patulin in 1 ml of DMSO
Storage-20°C. Protect from light.
Applications 
WarningsTOXIC. Patulin may be lethal if swallowed, inhaled or adsorbed through skin. Patulin has been proven to be carcinogenic and potentially mutagenic.
Classification Lactone Mycotoxin
Cell signaling reagent; apopotosis inducer
Related products 
 For Research use only. Not for Human or Drug use
GMP/API grade available on request

Patulin by Fermentek is not produced from or contains any ingredients from animal origin.

No genetically modified organisms are used.
Publications 
 Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmüller S.
Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria.
Food Chem Toxicol. 2008 Apr;46(4):1398-407
  McLaughlin J, Lambert D, Padfield PJ, Burt JP, O'Neill CA.
Toxicol In Vitro. 2009 Feb;23(1):83-9.
The mycotoxin patulin, modulates tight junctions in caco-2 cells.
  Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M.
Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1) proteins in skin of mice.
Toxicol Appl Pharmacol. 2009 Jan 15;234(2):192-201
  Wu TS, Liao YC, Yu FY, Chang CH, Liu BH.
Mechanism of patulin -induced apoptosis in human leukemia cells (HL-60).
Toxicol Lett. 2008 Dec 15;183(1-3):105-11
  Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A.
Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione.
Environ Toxicol. 2008 Feb;23(1):84-95.
AVAILABLE
Standard solutions

Patulin solution



Patulin was suggested as a remedy against common cold and reached clinical trials step in 1943 in Great Britain. However Patulin was found to be inefficient as such.
(International Journal of Epidemiology 2004;33:243–246)


rotten apple contaminated with patulin producing penicillium expansum
"Blue rot" - an apple contaminated with Patulin producing Penicillium expansum
 

...the European Union limit is 50 micrograms per kilogram (mcg/kg) for Patulin mycotoxin in both apple juice and cider.

The other established limits for Patulin are 25mcg/kg in solid apple products and 10mcg/kg in products for babies and young children. ...

 


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