|Source: ||Penicillium expansum|
|Description: ||Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.|
|CAS number: ||149-29-1|
|Merck index: ||12, 7185|
|Molecular weight: ||154.1|
|Molecular Formula: ||
|Patulin is soluble in DMSO, Methanol, Ethanol, water|
|Appearance: ||White crystalline solid.|
|Purity: ||At least 98% by TLC, HPLC|
|Solubility||Clear colorless solution at 10mg of Patulin in 1 ml of DMSO|
|Storage||-20°C. Protect from light.|
|Warnings||TOXIC. Patulin may be lethal if swallowed, inhaled or adsorbed through skin.
Patulin has been proven to be carcinogenic
and potentially mutagenic.|
Cell signaling reagent; apopotosis inducer
|Related products|| |
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
Patulin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
| ||Fuchs S, Sontag G, Stidl R,
Ehrlich V, Kundi M, Knasmüller S.|
Detoxification of patulin and
ochratoxin A, two abundant mycotoxins, by lactic acid bacteria.
Food Chem Toxicol. 2008 Apr;46(4):1398-407
McLaughlin J, Lambert D, Padfield PJ, Burt JP, O'Neill CA.|
Toxicol In Vitro. 2009
The mycotoxin patulin, modulates tight junctions in caco-2 cells.
Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M.|
Patulin causes DNA damage leading to
cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1)
proteins in skin of mice.
Toxicol Appl Pharmacol. 2009 Jan 15;234(2):192-201
Wu TS, Liao YC, Yu FY, Chang CH, Liu BH.|
Mechanism of patulin -induced apoptosis in
human leukemia cells (HL-60).
Toxicol Lett. 2008 Dec 15;183(1-3):105-11
Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A.|
Patulin influences the expression of
Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells
through depletion of intracellular glutathione.
Environ Toxicol. 2008 Feb;23(1):84-95.
Patulin was suggested as a remedy against
common cold and reached clinical trials step in 1943 in Great
Britain. However Patulin was found to be inefficient as such.
(International Journal of Epidemiology 2004;33:243–246)
"Blue rot" - an apple contaminated with Patulin producing Penicillium expansum
European Union limit is 50 micrograms
per kilogram (mcg/kg) for
Patulin mycotoxin in
both apple juice and cider.
The other established limits for
Patulin are 25mcg/kg in solid apple
products and 10mcg/kg in products for babies
and young children. ...