| Source: | Penicillium expansum |
| Synonyms | Clavacin,
Claviformin,
Mycoin C3 |
| Description: | Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase. |
| CAS number: | 149-29-1 |
| Merck index: | 12, 7185 |
| Molecular weight: | 154.1 |
| Structure: |
 |
| Molecular Formula: |
C7H6O4 |
| Canonical SMILES: |
C1C=C2C(=CC(=O)O2)C(O1)O |
Solubility
information: | Patulin is soluble in DMSO, Methanol, Ethanol, water |
| Specifications | |
| Appearance: | White crystalline solid. |
| Purity: | At least 98% by TLC, HPLC |
| λmax: | 276 |
| Melting point | 105°C-111°C |
| Solubility | Clear colorless solution at 10mg of Patulin in 1 ml of DMSO |
| Storage | -20°C. Protect from light. |
| Applications | |
| Warnings | TOXIC. Patulin may be lethal if swallowed, inhaled or adsorbed through skin.
Patulin has been proven to be carcinogenic
and potentially mutagenic. |
| Classification |
Lactone Mycotoxin
Cell signaling reagent; apopotosis inducer |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Patulin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Fuchs S, Sontag G, Stidl R,
Ehrlich V, Kundi M, Knasmüller S.
Detoxification of patulin and
ochratoxin A, two abundant mycotoxins, by lactic acid bacteria.
Food Chem Toxicol. 2008 Apr;46(4):1398-407 |
| |
McLaughlin J, Lambert D, Padfield PJ, Burt JP, O'Neill CA.
Toxicol In Vitro. 2009
Feb;23(1):83-9.
The mycotoxin patulin, modulates tight junctions in caco-2 cells. |
| |
Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M.
Patulin causes DNA damage leading to
cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1)
proteins in skin of mice.
Toxicol Appl Pharmacol. 2009 Jan 15;234(2):192-201 |
| |
Wu TS, Liao YC, Yu FY, Chang CH, Liu BH.
Mechanism of patulin -induced apoptosis in
human leukemia cells (HL-60).
Toxicol Lett. 2008 Dec 15;183(1-3):105-11 |
| |
Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A.
Patulin influences the expression of
Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells
through depletion of intracellular glutathione.
Environ Toxicol. 2008 Feb;23(1):84-95. |
|
AVAILABLE
Standard solutions |
Patulin solution
|
|
Patulin was suggested as a remedy against
common cold and reached clinical trials step in 1943 in Great
Britain. However Patulin was found to be inefficient as such.
(International Journal of Epidemiology 2004;33:243–246) |
"Blue rot" - an apple contaminated with Patulin producing Penicillium expansum |
|
...the
European Union limit is 50 micrograms
per kilogram (mcg/kg) for
Patulin mycotoxin in
both apple juice and cider.
The other established limits for
Patulin are 25mcg/kg in solid apple
products and 10mcg/kg in products for babies
and young children. ...
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