| Source: | Chrysanthemum parthenium ( a plant extract) |
| Synonyms | |
| Description: | Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium) |
| CAS number: | 20554-84-1 |
| Merck index: | 13,7120 |
| Molecular weight: | 248.3 |
| Structure: | 
 |
| Molecular Formula: | C15H20O3 |
| Canonical
SMILES: |
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C |
Solubility
information: |
Reportedly, maximum obtainable
serum levels were 200 nM.
DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane. |
| Specifications |
|
| Appearance: | White crystalline solid. |
| Purity: | At least 98% by TLC |
| λmax: | (in methanol) 209 |
| Melting point | 112°C-115°C |
| Solubility | Clear colorless solution at 5mg/ml Dichloromethane |
| Storage | -20°C. Avoid moisture. |
| Applications | Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase. |
| Warnings | Potentially harmful if ingested, inhaled, or absorbed through the skin. May cause allergic reaction. |
| Classification | sesquiterpene lactone
MAP kinase inhibitor |
| Related products |
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
 Parthenolide by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications |
|
| | Ralstin MC, Gage EA, Yip-Schneider MT, Klein PJ, Wiebke EA, Schmidt CM.
Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.
Mol Cancer Res. 2006 Jun;4(6):387-99 |
| | Lopez-Franco O, Hernandez-Vargas P, Ortiz-Munoz G, Sanjuan G, Suzuki Y, Ortega L, Blanco J, Egido J, Gomez-Guerrero C.
Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis.
Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1864-70 |
| | Steele AJ, Jones DT, Ganeshaguru K, Duke VM, Yogashangary BC, North JM, Lowdell MW, Kottaridis PD, Mehta AB, Prentice AG, Hoffbrand AV, Wickremasinghe RG.
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.
Leukemia. 2006 Jun;20(6):1073-9. |
| | Tassorelli C, Greco R, Morazzoni P, Riva A, Sandrini G, Nappi G.
Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.
Cephalalgia. 2005 Aug;25(8):612-21. |
| | Li-Weber M, Palfi K, Giaisi M, Krammer PH.
Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.
Cell Death Differ. 2005 Apr;12(4):408-9 |
| | Parada-Turska J, Paduch R, Majdan M, Kandefer-Szerszen M, Rzeski
Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells.
Pharmacol Rep. 2007 Mar-Apr;59(2):233-7 |
| | Zunino SJ, Ducore JM, Storms DH.
Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.
Cancer Lett. 2007 Apr 28 |
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Chrysanthemum parthenium (feverfew) |
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